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Off-label use for hyperbilirubinemia: Phenobarbital induces glucuronyl transferase and hepatic bilirubin-binding Y-protein to lessen serum bilirubin concentrationsObserve Carefully (one)somatropin will lower the level or influence of phenobarbital by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Barbiturates are respiratory depressants, and